Radius publishes data on its research in a variety of scientific or medical journals. Below are articles relating to our work in bone health.

View a listing of recent additional congress presentations.

September 2021
Development and Validation of a One Year Predictive Model for Secondary Fractures in Osteoporosis.
PLoS ONE. 2021;16(9):e0257246. Williams SA, Greenspan SL, Bancroft T, Chastek BJ, Wang Y, Weiss RJ, Pyrih N, Nichols H, Cauley JA.

July 2021
Economic Burden of Osteoporosis-Related Fractures in the US Medicare Population.
Annals of Pharmacother. 2021;55(7):821-829. Williams SA, Daigle SG, Weiss R, Wang Y, Arora T, Curtis JR

May 2021
Gender Disparities in Osteoporosis Screening and Management Among Older Adults.
Advances in Therapy. 2021;(38):3872-3887. Ramachandran S, Williams SA, Weiss RJ, Wang Y, Zhang Y, Nsiah I, Bhattacharya K.

Risk Factors for Incident Fracture in Older Adults With Type 2 Diabetes: The Framingham Heart Study.
Diabetes Care. 2021;44(7):1547-1555. Dufour AB, Kiel DP, Williams SA, Weiss RJ, Samelson EJ.

April 2021
Early Effects of Abaloparatide on Bone Formation and Resorption Indices in Postmenopausal Women With Osteoporosis.
J Bone Miner Res. 2021;36(4):644-653. Dempster DW, Zhou H, Rao SD, Recknor C, Miller PD, Leder BZ, Annett M, Ominsky MS, Mitlak BH.

March 2021
Abaloparatide Treatment Increases Bone Formation, Bone Density and Bone Strength Without Increasing Bone Resorption in a Rat Model of Hindlimb Unloading.
Bone. 2021;144:115801. Teguh DA, Nustad JL, Craven AE, Brooks DJ, Arlt H, Hu D, Baron R, Lanske B, Bouxsein ML.

February 2021
Phase 1b Evaluation of Abaloparatide Solid Microstructured Transdermal System (Abaloparatide-sMTS) in Postmenopausal Women with Low Bone Mineral Density.
Clinical Drug Evaluation. 2021;(41):277-285. Miller PD, Troy S, Weiss RJ, Annett M, Schense J, Williams SA, Mitlak B.

Abaloparatide Real-World Patient Experience Study.
JBMR Plus. 2021;5(3)e10457. Gold DT, Weiss RJ, Beckett T, Deal C, Epstein RS, James AL, Kernaghan JM, Mohseni M, Spiegel M, Vokes T, Roberts J, Bailey T, Wang Y, Williams SA.

January 2021
Differential Effects of Abaloparatide and Teriparatide on Hip Cortical Volumetric BMD by DXA-based 3D Modeling.
Osteoporosis International. 2021;(32):575-583. Winzenrieth R, Ominsky MS, Wang Y, Humbert L, Weiss RJ.

December 2020
Effects of Abaloparatide and Teriparatide on Bone Resorption and Bone Formation in Female Mice.
Bone Rep. 2020;13:100291. Arlt H, Mullarkey T, Hu D, Baron R, Ominsky MS, Mitlak B, Lanske B, Besschetnova T.

November 2020
Cardiovascular Safety of Abaloparatide in Postmenopausal Women with Osteoporosis: Analysis from the ACTIVE Phase 3 Trial.
J Clin Endocrinol Metab. 2020;105(11):3384-3395. Cosman F, Peterson LR, Towler DA, Mitlak B, Wang Y, Cummings SR.

October 2020
Abaloparatide: An Anabolic Treatment to Reduce Fracture Risk in Postmenopausal Women With Osteoporosis.
Current Medical Research and Opinion. 2020;36(11):1861-1872. Miller PD, Bilezikian JP, Fitzpatrick LA, Mitlak B, McCloskey EV, Cosman F, Bone HG.

Abaloparatide Followed by Alendronate in Women ≥80 Years With Osteoporosis: Post Hoc Analysis of ACTIVExtend.
Menopause. 2020;27(10):1137-1142. Greenspan SL, Fitzpatrick LA, Mitlak B, Wang Y, Harvey NC, Deal C, Cosman F, McClung M.

September 2020
Forearm Bone Mineral Density and Fracture Incidence in Postmenopausal Women With Osteoporosis: Results from the ACTIVExtend Phase 3 Trial.
Osteoporosis International. 2020:32;55-61. Watts NB, Dore RK, Baim S, Mitlak B, Hattersley G, Wang Y, Rozental TD, LeBoff MS.

July 2020
Characterizing Patients Initiating Abaloparatide, Teriparatide, or Denosumab in a Real-World Setting: a US Linked Claims and EMR Database Analysis
Osteoporosis International. 2020;31:2413-2424. Imel EA, Starzyk K, Gliklich R, Weiss RJ, Wang Y, Williams SA.

June 2020
Effect of Abaloparatide on Bone Mineral Density and Fracture Incidence in a Subset of Younger Postmenopausal Women with Osteoporosis at High Risk for Fracture.
Clin Ther. 2020;42(6):1099-1107. Saag KG, Williams SA, Wang Y, Weiss RJ, Cauley JA.

May 2020
Economic Burden of Osteoporotic Fractures in US Managed Care Enrollees.
Am J Manag Care. 2020; 26(5):e142-e149. Williams SA, Chastek B, Sundquist K, Barrera-Sierra S, Leader D, Weiss RJ, Wang Y, Curtis RJ.

February 2020
Cost-Effectiveness of Sequential Treatment with Abaloparatide followed by Alendronate vs. Alendronate Monotherapy in Women at Increased Risk of Fracture: a US Payer Perspective.
Semin Arthritis Rheum. 2020; 50(3):394-400. Hiligsmann M, Williams SA, Fitzpatrick LA, Silverman SS, Weiss R, Reginster J-Y.

Osteoporotic Fracture Trends in a Population of US Managed Care Enrollees from 2007 to 2017.
Osteoporosis International. 2020; 31(7):1299-1304. Lewiecki EM, Chastek B, Sundquist K, Williams SA, Weiss RJ, Wang Y, Fitzpatrick LA, Curtis JR.

Abaloparatide in Postmenopausal Women with Osteoporosis and Type 2 Diabetes: A Post-hoc Analysis of the ACTIVE Study.
JBMR Plus. 2020; 4(4):e10346. Dhaliwal R, Hans D, Hattersley G, Mitlak B, Fitzpatrick LA, Wang Y, Schwartz AV, Miller PD, Josse RG.

December 2019
Fracture and Bone Mineral Density Response by Baseline Risk in Patients Treated With Abaloparatide Followed by Alendronate: Results From the Phase 3 ACTIVExtend Trial.
J Bone Miner Res. 2019; 34(12):2213-2219. Leder BZ, Zapalowski C, Hu MY, Hattersley G, Lane NE, Singer AJ, Dore RK.

November 2019
Response Rates for Hip, Femoral Neck, and Lumbar Spine Bone Mineral Density in Patients Treated with Abaloparatide Followed by Alendronate: Results from Phase 3 ACTIVExtend.
Bone Reports. 2019; 11;100230. Deal CL, Mitlak BH, Wang Y, Fitzpatrick LA, Miller PD.

Effect of Abaloparatide versus Alendronate on Fracture Risk Reduction in Postmenopausal Women with Osteoporosis.
J Clin Endocrinol Metab. 2019; 105(3). Leder BZ, Mitlak B, Hu MY, Hattersley G, Bockman RS.

October 2019
Impact of Fractures on Quality of Life in Patients with Osteoporosis: a US Cross-Sectional Survey.
J Drug Assess. 2019; 8(1):175-183. Gold T, Williams SA, Weiss RJ, Wang Y, Watkins C, Carroll J, Middleton C, Silverman S.

August 2019
Abaloparatide In Patients with Mild or Moderate Renal Impairment: Results from the ACTIVE Phase 3 Trial.
Curr Med Res Opin. 2019; 35(12):2097-2102. Bilezikian JP, Hattersley G, Mitlak BH, Hu MY, Fitzpatrick LA, Dabrowski C, Miller PD, Papapoulos SE.

July 2019
Abaloparatide Improves Cortical Geometry and Trabecular Microarchitecture and Increases Vertebral and Femoral Neck Strength in a Rat Model of Male Osteoporosis.
BONE. 2019; 124:148-157. Besschetnova T, Brooks DJ, Hu D, Nagano K, Nustad J, Ominsky M, Mitlak B, Hattersley G, Bouxsein ML, Baron R, Lanske B.

April 2019
Abaloparatide for Risk Reduction of Nonvertebral and Vertebral Fractures in Postmenopausal Women with Osteoporosis: a Network Meta-Analysis.
Osteoporosis International. 2019; 30(7):1465-1473. Reginster JY, Bianic F, Campbell R, Martin M, Williams SA, Fitzpatrick LA.

March 2019
Abaloparatide Effect on Forearm Bone Mineral Density and Wrist Fracture Risk in Postmenopausal Women with Osteoporosis.
Osteoporosis International. 2019; 30(6):1187-1194. Watts NB, Hattersley G, Fitzpatrick LA, Wang Y, Williams GC, Miller PD, Cosman F.

February 2019
Challenges in Osteoporosis Awareness and Management: Results from a Survey of US Postmenopausal Women.
Journal of Drug Assessment. 2019; 8(1):25-31. Lewiecki EM, Leader D, Weiss R, Williams SA.

Abaloparatide, a PTH receptor agonist with homology to PTHrP, enhances callus bridging and biomechanical properties in rats with femoral fracture.
Journal of Orthopaedic Research. 2019; 37(4):812-820. Lanske B, Chandler H, Pierce A, Brown J, Ominsky M, Kostenuik P, Hattersley G.

Effect of abaloparatide on vertebral, nonvertebral, major osteoporotic, and clinical fractures in a subset of postmenopausal women at increased risk of fracture by FRAX probability.
Archives of Osteoporosis. 2019;14(1):15. McCloskey EV, Fitzpatrick LA, Hu MY, Williams G, Kanis JA.

January 2019
Cost-effectiveness of sequential treatment with abaloparatide vs. teriparatide for United States women at increased risk of fracture.
Seminars in Arthritis and Rheumatism. 2019; 49(2):184-196. Hiligsmann M, Williams SA, Fitzpatrick LA, Silverman SS, Weiss R, Reginster JY.

Bone Turnover Markers to Explain Changes in Lumbar Spine BMD with Abaloparatide and Teriparatide: Results from ACTIVE.
Osteoporos Int. 2019; 30(3):667-673. Eastell R, Mitlak B, Wang Y, Hu MY, Fitzpatrick LA, Black DM.

October 2018
Bone mineral density response rates are greater in patients treated with abaloparatide compared with those treated with placebo or teriparatide: Results from the ACTIVE phase 3 trial.
Bone. 2018;120:137-140. Miller PD, Hattersley G, Lau E, Fitzpatrick LA, Harris AG, Williams GC, Hu MY, Riis BJ, Russo L, Christiansen C.

Abaloparatide, a novel osteoanabolic PTHrP analog, increases cortical and trabecular bone mass and architecture in orchiectomized rats by increasing bone formation without increasing bone resorption.
Bone. 2018;120:148-155. Chandler H, Lanske B, Varela A, Guillot M, Boyer M, Brown J, Pierce A, Ominsky M, Mitlak B, Baron R, Kostenuik P, Hattersley G.

August 2018
Cost-effectiveness Analysis of Sequential Treatment of Abaloparatide Followed by Alendronate Versus Teriparatide Followed by Alendronate in Postmenopausal Women With Osteoporosis in the United States.
Ann Pharmacother. 2018;53(2):134-143. Le QA, Hay JW, Becker R, Wang Y.

July 2018
Effects of abaloparatide on bone mineral density and risk of fracture in postmenopausal women aged 80 years or older with osteoporosis.
Menopause. 2018;25:767-771. McClung MR, Harvey NC, Fitzpatrick LA, Miller PD, Hattersley G, Wang Y, Cosman F.

June 2018
Abaloparatide is an Effective Treatment Option for Postmenopausal Osteoporosis: Review of the Number Needed to Treat Compared with Teriparatide
Calcif Tissue Int. 2018;103:540-545. Reginster JY, Hattersley G, Williams GC, Hu MY, Fitzpatrick LA, Lewiecki EM.

May 2018
ACTIVExtend: 24 Months of Alendronate after 18 Months of Abaloparatide or Placebo for Postmenopausal Osteoporosis.
J Clin Endocrinol Metab. 2018;103:2949-2957. Bone HG, Cosman F, Miller PD, Williams GC, Hattersley G, Hu M-y, Fitzpatrick LA, Mitlak B, Papapoulos S, Rizzoli R, Dore RK, Bilezikian JP, Saag KG.

December 2017
Geography of Fracture Incidence in Postmenopausal Women with Osteoporosis Treated with Abaloparatide.
Calcif Tissue Int. 2018;102:627-633. McClung MR, Williams GC, Hattersley G, Fitzpatrick LA, Wang Y, Miller PD.

Abaloparatide, a novel PTH receptor agonist, increased bone mass and strength in ovariectomized cynomolgus monkeys by increasing bone formation without increasing bone resorption.
Osteoporos Int. 2018;29:685-697. Doyle N, Varela A, Haile S, Guldberg R, Kostenuik PJ, Ominsky MS, Smith SY, Hattersley G.

November 2017
Abaloparatide-SC improves trabecular microarchitecture as assessed by trabecular bone score (TBS): a 24-week randomized clinical trial.
Osteoporos Int. 2018;29:323-328. Bilezikian JP, Hattersley G, Fitzpatrick LA, Harris AG, Shevroja E, Banks K, Leder BZ, Zanchetta JR, Hans D.

August 2017
The Effect of Abaloparatide-SC on Fracture Risk Is Independent of Baseline FRAX Fracture Probability: A Post Hoc Analysis of the ACTIVE Study.
J Bone Miner Res. 2017;32:1625-1631. McCloskey EV, Johansson H, Oden A, Harvey NC, Jiang H, Modin S, Fitzpatrick L, Kanis JA.

June 2017
Comparing the incidence of bone tumors in rats chronically exposed to the selective PTH type 1 receptor agonist abaloparatide or PTH(1-34).
Regul Toxicol Pharmacol. 2017;86:356-365. Jolette J, Attalla B, Varela A, Long GG, Mellal N, Trimm S, Smith SY, Ominsky MS, Hattersley G.

April 2017
Effects of abaloparatide-SC (BA058) on bone histology and histomorphometry: the ACTIVE phase 3 trial.
Bone. 2017;97:314-319. Moreira C, Fitzpatrick LA, Wang Y, Recker RR.

February 2017
Eighteen months of treatment with subcutaneous abaloparatide followed by 6 months of treatment with alendronate in postmenopausal women with osteoporosis: results of the ACTIVExtend trial.

Mayo Clin Proc. 2017;92:200-210. Cosman F, Miller PD, Williams GC, Hattersley G, Hu MY, Valter I, Fitzpatrick LA, Riis BJ, Christiansen C, Bilezikian JP, Black D.

One year of abaloparatide, a selective peptide activator of the PTH1 receptor, increased bone mass and strength in ovariectomized rats.
Bone. 2017;95:143-150. Varela A, Chouinard L, Lesage E, Guldberg R, Smith SY, Kostenuik PJ, Hattersley G.

January 2017
One year of abaloparatide, a selective activator of the PTH1 receptor, increased bone formation and bone mass in osteopenic ovariectomized rats without increasing bone resorption.
J Bone Miner Res. 2017;32:24-33. Varela A, Chouinard L, Lesage E, Smith SY, Hattersley G.

Effects of abaloparatide-SC on fractures and bone mineral density in subgroups of postmenopausal women with osteoporosis and varying baseline risk factors.
J Bone Miner Res. 2017;32:17-23. Cosman F, Hattersley G, Hu MY, Williams GC, Fitzpatrick LA, Black DM.

November 2016
Six weeks of daily abaloparatide treatment increased vertebral and femoral bone mineral density, microarchitecture and strength in ovariectomized osteopenic rats.
Calcif Tissue Int. 2016;99:489-499. Bahar H, Gallacher K, Downall J, Nelson CA, Shomali M, Hattersley G.

August 2016
Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis: a randomized clinical trial.

JAMA. 2016;316:722-733. Miller PD, Hattersley G, Riis BJ, Williams GC, Lau E, Russo LA, Alexandersen P, Zerbini CA, Hu MY, Harris AG, Fitzpatrick LA, Cosman F, Christiansen C; ACTIVE Study Investigators.

January 2016
Binding selectivity of abaloparatide for PTH-type-1-receptor conformations and effects on downstream signaling.
Endocrinology. 2016;157:141-149. Hattersley G, Dean T, Corbin BA, Bahar H, Gardella TJ.

February 2015
Effects of abaloparatide, a human parathyroid hormone-related peptide analog, on bone mineral density in postmenopausal women with osteoporosis.
J Clin Endocrinol Metab. 2015;100:697-706. Leder BZ, O’Dea LS, Zanchetta JR, Kumar P, Banks K, McKay K, Lyttle CR, Hattersley G.